Week 10 NFL Picks: Undefeated San Francisco hosts division rival Seattle in Monday night showdown

Game of the week

Seattle at San Francisco

A Monday night clash between the 8-0 49ers (a six-point favorite) and 6-2 Seahawks, the first of two meetings. If San Francisco wins, it will have a three-game NFC West lead with seven games remaining and is in driver’s seat for home-field advantage. If Seattle wins, it still has a chance to win the division. Seahawks 24, 49ers 21

Lock of the week

Atlanta at New Orleans

Both teams are coming off their bye weeks and headed in opposite directions. The 1-7 Falcons lead the NFL in passing yards (316.8) because they are always playing from behind. The Saints, a 12 1/2-point favorite, have a top-10 defense in yards, points and third down. Saints 42, Falcons 24

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Upset of the week

Buffalo at Cleveland

Why are the Bills (6-2) a 2 1/2-point road underdog to the reeling Browns (2-6)? It’s really weird: The Bills are 3-0 on the road this year and the Browns are 0-3 at home. Buffalo’s third-ranked defense adds to the misery of quarterback Baker Mayfield. Bills 23, Browns 17